Miraculous Medicines

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1002 Defibrotide
075eb3b381932c0b44483d2443dae93f8c70b1ecf7cc322a62bb2a02131dd768

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Properties

Chemistry

Defibrotide, sold under the brandname Defitelio, is a mixture of single-stranded oligonucleotides that is purified from the intestinal mucosa of pigs. It is used to treat veno-occlusive disease of the liver of people having had a bone marrow transplant, with different limitations in the US and the European Union. It works by protecting the cells lining blood vessels in the liver and preventing blood clotting; the way it does this is not well understood.

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