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1228 Daclatasvir
3405a363de2065cb8f89dc7ac4642f3e7a306ffb6f9ab939826d3684f8e6242e

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Properties

Chemistry

Daclatasvir, sold under the trade name Daklinza, is a medication used in combination with other medications to treat hepatitis C (HCV).1 The other medications used in combination include sofosbuvir, ribavirin, and interferon, vary depending on the virus type and whether the person has cirrhosis.2 In significant difference to previous HCV therapies, Daclatasvir has the advantage of being taken orally in low application rates of normally 60 mg once daily with or without meals. This is caused by the marginal EC50 of Daclatasvir. In genotype 1a Daclatasvir shows an EC50 of 0,0044 ng/ml and against genotype 1b the EC50 takes the lowest value with 0,0019 ng/ml. The average application takes a duration of either 12 or 24 weeks.345 The drug DAKLINZA ™ is available in forms of 30, 60, 90 mg film-coated tablets.6

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