Minted: - / 5000

1271 Licostinel
c21b9d0f44a423093beadf4540f7203b7dfbbeb1909334538a4c6880d4a94324

Properties

Background

Gray
Bottle

Purple
Cap

Light blue
Syringe

Green
Bubbles
No
Drops
Yes
Label
Drop

Chemistry

Formula
C8H3Cl2N3O4
Carbon
8
Polarity
Neutral

Licostinel (INN) (code name ACEA-1021) is a competitive, silent antagonist of the glycine site of the NMDA receptor (K_b = 5 nM). It was under investigation by Acea Pharmaceuticals as a neuroprotective agent for the treatment of cerebral ischemia associated with stroke and head injuries but was ultimately never marketed. In clinical trials, licostinel did not produce phencyclidine-like psychotomimetic effects at the doses tested, though transient sedation, dizziness, and nausea were observed. In addition to its actions at the NMDA receptor, licostinel also acts as an antagonist of the AMPA and kainate receptors at high concentrations (K_b = 0.9 μM and 2.5 μM, respectively).

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