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1653 Demecolcine
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Properties

Background

Orange
Bottle

Green
Cap

Light blue
Syringe

Light green
Bubbles
No
Drops
No
Label
Leaf

Chemistry

Formula
C21H25NO5
Carbon
21
Polarity
Neutral

Demecolcine (INN; also known as colcemid) is a drug used in chemotherapy. It is closely related to the natural alkaloid colchicine with the replacement of the acetyl group on the amino moiety with methyl, but it is less toxic. It depolymerises microtubules and limits microtubule formation (inactivates spindle fibre formation), thus arresting cells in metaphase and allowing cell harvest and karyotyping to be performed.

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