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1720 Dantrolene
7010d431b007977a540d41f7d7a1f4aa7e4868ef34c2bb823bf6b0f8d10fe253

Properties

Background

Red
Bottle

Light blue
Cap

Gray
Syringe

Light blue
Bubbles
No
Drops
Yes
Label
Pill

Chemistry

Formula
C14H10N4O5
Carbon
14
Polarity
Neutral

Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. It achieves this by inhibiting Ca²⁺ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. It is the primary drug used for the treatment and prevention of malignant hyperthermia, a rare, life-threatening disorder triggered by general anesthesia. It is also used in the management of neuroleptic malignant syndrome, muscle spasticity (e.g. after strokes, in paraplegia, cerebral palsy, or patients with multiple sclerosis), and poisoning by 2,4-dinitrophenol or by the related compounds dinoseb and dinoterb.

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