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1802 Lysergic acid 2,4-dimethylazetidide
63b1fcd9a6060b2fc536789b56f3c454709ec3cc26bec8fff5eea8022fa9ff68

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Properties

Chemistry

Lysergic acid 2,4-dimethylazetidide (LA-SS-Az, LSZ) is an analog of LSD developed by the team led by David E. Nichols at Purdue University. It was developed as a rigid analog of LSD with the diethylamide group constrained into an azetidine ring in order to map the binding site at the 5-HT2A receptor. There are three possible stereoisomers around the azetidine ring, with the (S,S)-(+) isomer being the most active, slightly more potent than LSD itself in drug discrimination tests using trained rats.

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