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1824 Bifemelane
ac19b1b3dff45e1c3e33f444b79d2bfdf14203d7ab065d5e05ab307e69558b7d

Properties

Background

Orange
Bottle

Gray
Cap

Blue
Syringe

Light green
Bubbles
No
Drops
No
Label
Drop

Chemistry

Formula
C18H23NO
Carbon
18
Polarity
Neutral

Bifemelane (INN) (Alnert, Celeport), or bifemelane hydrochloride (JAN), also known as 4-(O-benzylphenoxy)-N-methylbutylamine, is an antidepressant and cerebral activator that is widely used in the treatment of cerebral infarction patients with depressive symptoms in Japan, and in the treatment of senile dementia as well. It also appears to be useful in the treatment of glaucoma. Bifemelane acts as a monoamine oxidase inhibitor (MAOI) of both isoenzymes, with competitive (reversible) inhibition of MAO-A (K_i = 4.20 μM) (making it a reversible inhibitor of monoamine oxidase A (RIMA)) and non-competitive (irreversible) inhibition of MAO-B (K_i = 46.0 μM), and also acts (weakly) as a norepinephrine reuptake inhibitor. The drug has nootropic, neuroprotective, and antidepressant-like effects in animal models, and appears to enhance the cholinergic system in the brain.

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