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1848 Lofexidine
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Lofexidine, sold under the brand name Lucemyra among others, is a medication historically used to treat high blood pressure; today, it is more commonly used to help with the physical symptoms of opioid withdrawal. It is taken by mouth. It is an α_2A adrenergic receptor agonist. It was approved for use by the Food and Drug Administration in the United States in 2018.

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