Minted: - / 5000

1904 Diarylpropionitrile
648f2378a18250a4ed58bc232886cc4408f8811344a6f4756e4b6f32daabf996

Properties

Background

Blue
Bottle

Green
Cap

Blue
Syringe

Red
Bubbles
No
Drops
Yes
Label
Leaf

Chemistry

Formula
C15H13NO2
Carbon
15
Polarity
Neutral

Diarylpropionitrile (DPN), also known as 2,3-bis(p-hydroxyphenyl)propionitrile (2,3-BHPPN), is a synthetic, nonsteroidal, and highly selective agonist of ERβ (IC₅₀ = 15 nM) that is used widely in scientific research to study the function of this receptor. It is 70-fold more selective for ERβ over ERα, and has 100-fold lower affinity for GPER (GPR30) relative to estradiol. DPN produces antidepressant- and anxiolytic-like effects in animals via activation of the endogenous oxytocin system. First reported in 2001, DPN was the first selective ERβ agonist to be discovered, and was followed by prinaberel (ERB-041, WAY-202041), WAY-200070, and 8β-VE2 in 2004, ERB-196 (WAY-202196) in 2005, and certain phytoestrogens like liquiritigenin and nyasol (cis-hinokiresinol) since 2007.

From Wikipedia, the free encyclopedia. License: CC BY-SA.