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1908 Piretanide
08f44894c8aaea4b650438119433e0a9e5c480a54d9e6de51ab6c5a9e9954a24

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Properties

Chemistry

Piretanide is a loop diuretic compound by using a then-new method for introducing cyclic amine residues in an aromatic nucleus in the presence of other aromatically bonded functional groups. Studies of piretanide in rats and dogs in comparison with other high-ceiling diuretics such as furosemide and bumetanide found a more suitable dose/response rate (regression line) and a more favourable sodium/potassium excretion ratio. These findings led eventually to studies in man and finally to the introduction as a saluretic and antihypertensive medication in Germany, France, Italy and other countries.

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