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1925 Zyklophin
a37bf284576f02ed6cc23d0f4c7fa18ce6e584cb686a456ee800b7d0947a1539

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Properties

Chemistry

Zyklophin is a semisynthetic peptide derived from dynorphin A and a highly selective antagonist of the κ-opioid receptor (KOR). It is systemically-active, displaying good metabolic stability and blood-brain-barrier penetration. Similarly to other KOR antagonists, it has been shown to block stress-induced reinstatement of cocaine-seeking in animals. The drug is currently experimental, and thus cannot be considered safe for consumption or usage.

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