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2019 Bisantrene
0d1e38f803e9b20db8e5bfd16fc858b0b1b5e87d648e3378ac51bfbf049918e2

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Properties

Chemistry

Bisantrene, trademarked as Zantrene, is an anthracenyl bishydrazone with anthracycline-like antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike anthracyclines like doxorubicin, exhibits little cardiotoxicity.

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