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2297 Fosmidomycin
700e706a6738e66a7411c0ad16a59883aff585e687f3fcc3cfad52b796af8e24

Properties

Background

Brown
Bottle

Green
Cap

Orange
Syringe

Yellow
Bubbles
No
Drops
No
Label
Leaf

Chemistry

Formula
C4H10NO5P
Carbon
4
Polarity
Neutral

Fosmidomycin is an antibiotic that was originally isolated from culture broths of bacteria of the genus Streptomyces. It specifically inhibits DXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. It is a structural analogue of 2-C-methyl-D-erythrose 4-phosphate. It inhibits the E. coli enzyme with a KI value of 38 nM (4), MTB at 80 nM, and the Francisella enzyme at 99 nM. Several mutations in the E. coli DXP reductoisomerase were found to confer resistance to fosmidomycin.

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