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2324 Apaziquone
17891af9bddc3fe3660137fe8cb1eb8fbbb17a3b3f00247115fe8332fc6ce838

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Properties

Chemistry

Apaziquone (tentative trade name EOquin) is an indolequinone that is a bioreductive prodrug similar to the older chemotherapeutic agent mitomycin C. In hypoxic cells, such as those on the inner surface of the urinary bladder, apaziquone is converted to active metabolites by intracellular reductases. The active metabolites alkylate DNA and lead to apoptosis. This activity is preferentially expressed in neoplastic cells.

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