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2344 Omapatrilat
38fb8ff921b8a6313696287f72be4390d655ea4e8ce526b95d4eb3991d850e75

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Properties

Chemistry

Omapatrilat (INN, proposed trade name Vanlev) is an experimental antihypertensive agent that was never marketed. It inhibits both neprilysin (neutral endopeptidase, NEP) and angiotensin-converting enzyme (ACE). NEP inhibition results in elevated natriuretic peptide levels, promoting natriuresis, diuresis, vasodilation, and reductions in preload and ventricular remodeling.

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