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2349 Estradiol 3-saccharinylmethyl ether
df6217e5e65e7930b2f55fe802c1f71451ccb0364c318904de926e3c446e320d

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Properties

Chemistry

Estradiol 3-saccharinylmethyl ether (E2SME), also known as 3-O-(saccharinylmethyl)-17β-estradiol, is a synthetic estrogen and estrogen ether – specifically, the C3 saccharinylmethyl ether of estradiol – which was described in the mid-1990s and was never marketed. It is a prodrug of estradiol and appears to be partially protected from first-pass metabolism in the liver and intestines with oral administration, showing greatly improved oral potency compared to estradiol.

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