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2473 Trovafloxacin
6a7c0339066aa6f9d110cc0bdbfbef9e241cc72f2a3b937c8b0993b472c1c94f

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Properties

Chemistry

Trovafloxacin (sold as Trovan by Pfizer and Turvel by Laboratorios Almirall) is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was withdrawn from the market due to the risk of hepatotoxicity. It had better Gram-positive bacterial coverage and less Gram-negative coverage than the previous fluoroquinolones.

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