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2564 Tipifarnib
178ac563e6058a4f17b5d0a28182bfe4dd5c5b993fb5174e7f3244223bdc1922

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Properties

Chemistry

Tipifarnib (INN, proposed trade name Zarnestra) is a farnesyltransferase inhibitor. Farnesyltransferase inhibitors block the activity of the farnesyltransferase enzyme by inhibiting prenylation of the CAAX tail motif, which ultimately prevents Ras from binding to the membrane, rendering it inactive.

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