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2678 Filaminast
bec4191352900b9a58476c8adeeaa610d2c144744609867269647cb2fde6d44f

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Properties

Chemistry

Filaminast (code name WAY-PDA 641) was a drug candidate developed by Wyeth-Ayerst. It is a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and an analog of rolipram, which served as a prototype molecule for several development efforts. It was discontinued after a Phase II trial showed that its therapeutic window was too narrow; it could not be dosed high enough without causing significant side effects (nausea and vomiting), which was a problem with the rolipram class of molecules.

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