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269 Estrone sulfamate
d77c2b0792fd74078242e7399e0fbfc5c508ee8121a16161e5e1b61aa6d8547d

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Properties

Chemistry

Estrone sulfamate (EMATE; developmental code name J994), or estrone-3-O-sulfamate, is a steroid sulfatase (STS) inhibitor which has not yet been marketed. It is the C3 sulfamate ester of the estrogen estrone. Unlike other estrogen esters however, EMATE is not an effective prodrug of estrogens. A closely related compound is estradiol sulfamate (E2MATE), which is extensively metabolized into EMATE and has similar properties to it.

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