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2701 Talsaclidine
41b401f8d823bb3d03af7e038550b5cb5d06312694ac30be7a9057e926bc0675

Properties

Background

Orange
Bottle

Pink
Cap

Blue
Syringe

Yellow
Bubbles
Yes
Drops
No
Label
Pill

Chemistry

Formula
C10H15NO
Carbon
10
Polarity
Neutral

Talsaclidine (WAL-2014) is a non-selective muscarinic acetylcholine receptor agonist which acts as a full agonist at the M₁ subtype, and as a partial agonist at the M₂ and M₃ subtypes. It was under development for the treatment of Alzheimer's disease but showed only modest or poor efficacy in rhesus monkeys and humans, respectively, perhaps due to an array of dose-limiting side effects including increased heart rate and blood pressure, increased salivation, urinary frequency and burning upon urination, increased lacrimation and nasal secretion, abnormal accommodation, heartburn, upset stomach as well as cramps, nausea, vomiting and diarrhea, excessive sweating and palpitations.

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