Minted: - / 5000

2977 Vixotrigine
4e0ae7319386f286c64846b40405ae740a4f31f2575575519ae190718ce56feb

Properties

Background

Red
Bottle

Pink
Cap

Yellow
Syringe

Gray
Bubbles
No
Drops
Yes
Label
-

Chemistry

Formula
C18H19FN2O2
Carbon
18
Polarity
Neutral

Vixotrigine (, ), formerly known as raxatrigine (, ), is an analgesic which is under development by Convergence Pharmaceuticals for the treatment of lumbosacral radiculopathy (sciatica) and trigeminal neuralgia (TGN). Vixotrigine was originally claimed to be a selective central Na_v1.3 blocker, but was subsequently redefined as a selective peripheral Na_v1.7 blocker. Following this, vixotrigine was redefined once again, as a non-selective voltage-gated sodium channel blocker. As of January 2018, it is in phase III clinical trials for trigeminal neuralgia and is in phase II clinical studies for erythromelalgia and neuropathic pain. It was previously under investigation for the treatment of bipolar disorder, but development for this indication was discontinued.

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