Minted: - / 5000

301 Buprenorphine-3-glucuronide
080d45dc0cf7842c2fd4b3628ffcd0e84b6cfb1c64f6ec7d314013dbd24cbdb6

Properties

Background

Red
Bottle

Pink
Cap

Light blue
Syringe

Yellow
Bubbles
No
Drops
No
Label
Cross

Chemistry

Formula
C35H49NO10
Carbon
35
Polarity
Neutral

Buprenorphine-3-glucuronide (B3G) is a major active metabolite of the opioid modulator buprenorphine. It has affinity for the μ-opioid receptor (K_i = 4.9 (± 2.7) pM), δ-opioid receptor (K_i = 270 nM), and nociceptin receptor (K_i = 36 μM), but not for the κ-opioid receptor. Whether B3G acts as an agonist or antagonist of each of the former three respective sites has yet to be determined. In rats, at the doses assayed, B3G has been found to produce a small degree of antinociception, and similarly to buprenorphine in these assays, has not been found to produce sedation, reduce locomotion, or decrease respiratory rate. Of all of the active metabolites of buprenorphine, B3G is thought to be the most similar to the parent drug. Unlike norbuprenorphine, but similarly to buprenorphine (and norbuprenorphine-3-glucuronide), B3G is not a substrate for P-glycoprotein, and hence may cross the blood-brain-barrier significantly.

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