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3112 Decoglurant
148bc61e19b95fbb61af502fba56b04e6d0a3f9bbbd47064ab6dfc7d7e96a311

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Properties

Chemistry

Decoglurant (INN) (code name RG1578, RO4995819) is a negative allosteric modulator of the mGlu2 and mGlu3 receptors which was under development by Roche for the adjunctive treatment of major depressive disorder. Decoglurant progressed as far as phase II clinical trials but was ultimately discontinued from further development due to disappointing efficacy results.

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