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3188 Rolipram
9f9aa31a427d302cf4107497ac8bbf6b781a1a881f00633c53345b52a8b5e4c8

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Properties

Chemistry

Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s. It served as a prototype molecule for several companies' drug discovery and development efforts. Rolipram was discontinued after clinical trials showed that its therapeutic window was too narrow; it could not be dosed at high enough levels to be effective without causing significant gastrointestinal side effects.

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