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3221 Apararenone
fde744d40c26cda0ed48f75ba35b4043fcd34bca0fee18872a404ee44f7bebcd

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Properties

Chemistry

Apararenone (INN) (developmental code name MT-3995) is a nonsteroidal antimineralocorticoid which is under development by Mitsubishi Tanabe Pharma for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis. It was also previously being developed for the treatment of hypertension, but development was discontinued for this indication. Apararenone acts as a highly selective antagonist of the mineralocorticoid receptor (Ki < 50 nM), the receptor for aldosterone. As of 2017, it is in phase II clinical trials.

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