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3331 Naphthylpiperazine
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Properties

Background

Green
Bottle

Purple
Cap

Yellow
Syringe

Pink
Bubbles
No
Drops
Yes
Label
Bacterium

Chemistry

Formula
C14H16N2
Carbon
14
Polarity
Neutral

1-(1-Naphthyl)piperazine (1-NP) is a drug which is a phenylpiperazine derivative. It acts as a non-selective, mixed serotonergic agent, exerting partial agonism at the 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-HT_1E, and 5-HT_1F receptors, while antagonizing the 5-HT_2A, 5-HT_2B, and 5-HT_2C receptors. It has also been shown to possess high affinity for the 5-HT₃, 5-HT_5A, 5-HT₆, and 5-HT₇ receptors, and may bind to 5-HT₄ and the SERT as well. In animals it produces effects including hyperphagia, hyperactivity, and anxiolysis, of which are all likely mediated predominantly or fully by blockade of the 5-HT_2C receptor.

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