Minted: - / 5000

3415 Esaxerenone
c615afff21d663da3fa834e730fe42cde6b36e4bcd88147a3a2c066a9f2f544e

Properties

Background

Orange
Bottle

Red
Cap

Red
Syringe

Yellow
Bubbles
No
Drops
Yes
Label
Leaf

Chemistry

Formula
C22H21F3N2O4S
Carbon
22
Polarity
Neutral

Esaxerenone (brand name Minnebro; developmental code names CS-3150, XL-550) is a nonsteroidal antimineralocorticoid which was discovered by Exelixis and developed by Daiichi Sankyo Company and is approved in Japan for the treatment of hypertension. It acts as a highly selective silent antagonist of the mineralocorticoid receptor (MR), the receptor for aldosterone, with greater than 1,000-fold selectivity for this receptor over other steroid hormone receptors, and 4-fold and 76-fold higher affinity for the MR relative to the existing antimineralocorticoids spironolactone and eplerenone. As of January 2019, esaxerenone is in phase III clinical trials for diabetic nephropathies.

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