Minted: - / 5000

3436 Toripristone
2d0bb2cc1f4fce014bc1c68ae8a25f33fb22a3ac59dc5815e40b159d404f11b1

Properties

Background

Blue
Bottle

Blue
Cap

Light green
Syringe

Yellow
Bubbles
No
Drops
No
Label
Heart

Chemistry

Formula
C31H39NO2
Carbon
31
Polarity
Neutral

Toripristone (INN) (developmental code name RU-40555) is a synthetic, steroidal antiglucocorticoid as well as antiprogestogen which was never marketed. It is reported as a potent and highly selective antagonist of the glucocorticoid receptor (GR) (K_i = 2.4 nM), though it also acts as an antagonist of the progesterone receptor (PR). The pharmacological profile of toripristone is said to be very similar to that of mifepristone, except that toripristone does not bind to orosomucoid (α1-acid glycoprotein). The drug has been used to study the hypothalamic-pituitary-adrenal axis and has been used as a radiotracer for the GR. Its INN was given in 1990.

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