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3573 Cyanodothiepin
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Properties

Background

Green
Bottle

Purple
Cap

Blue
Syringe

Light green
Bubbles
No
Drops
No
Label
Cross

Chemistry

Formula
C20H20N2S
Carbon
20
Polarity
Neutral

Cyanodothiepin (developmental code name BTS-56424) is a tricyclic antidepressant (TCA) acting as a potent and highly selective (over norepinephrine and dopamine uptake) inhibitor of the reuptake of serotonin that was never marketed. It also has moderate affinity for the muscarinic acetylcholine receptors and weak/negligible affinity for the α₁-adrenergic, 5-HT_2A, D₁, and D₂ receptors; the H₁ receptor has not been assayed, but cyanodothiepin is less sedating than the related drug cianopramine, suggesting that its antihistamine activity is not as pronounced as other TCAs. Cyanodothiepin is active in the forced swimming test (FST), implying that it may possess antidepressant properties in humans. However, it is only weakly active compared to cianopramine and imipramine in monoamine depletion-based tests of antidepressant potential.

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