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3769 Oxymetazoline
27ba3ac7b1232ac551ce43e375cff25fe841a11f5fc5689030249e26182a15d1

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Properties

Chemistry

Oxymetazoline, an imidazole derivative, is a topical decongestant, used in the form of oxymetazoline hydrochloride. It was developed from xylometazoline at E. Merck Darmstadt by Wolfgang Fruhstorfer and Helmut Müller-Calgan in 1961. Oxymetazoline is generally available as a nasal spray. A direct sympathomimetic, Oxymetazoline binds to α1 adrenergic receptors and α2 adrenergic receptors, most notably. One study classified it in the following order: α(2A) > α(1A) ≥ α(2B) > α(1D) ≥ α(2C) >> α(1B), but this is not universally agreed upon. There is little consistency across the (relatively large) number of in-vitro studies with respect to binding affinity/selectivity.

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