Miraculous Medicines

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3866 Rosiglitazone
6b338e3f44f3d8f973581acb28c2fee4aa4bdef55f2eb5f5afa5b0e68765fc8f

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Properties

Chemistry

Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceutical company GlaxoSmithKline (GSK) as a stand-alone drug or for use in combination with metformin or with glimepiride. First released in 1999, annual sales peaked at approximately $2.5-billion in 2006; however, following a meta-analysis in 2007 that linked the drug's use to an increased risk of heart attack, sales plummeted to just $9.5-million in 2012. The drug's patent expired in 2012.

From Wikipedia, the free encyclopedia. License: CC BY-SA.
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