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3945 Oprozomib
108ecbb51ff253c5fd693be686dc5f8319b0af20420fbb27f2a58b9ff9f43f8a

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Properties

Chemistry

Oprozomib (codenamed ONX 0912 and PR-047) is an orally active second-generation proteasome inhibitor developed by Proteolix, which was acquired by Onyx Pharmaceuticals, an Amgen subsidiary, in 2009. It selectively inhibits chymotrypsin-like activity of both the constitutive proteasome (PSMB5) and immunoproteasome (LMP7).

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