Minted: - / 5000

3980 Cyclodiol
15d6f9fd06b1c1e0c8202e2be658ea794fdecd679f8e34be87b8d92bc0ca9d29

Properties

Background

Green
Bottle

Green
Cap

Red
Syringe

Yellow
Bubbles
No
Drops
No
Label
Drop

Chemistry

Formula
C20H26O2
Carbon
20
Polarity
Neutral

Cyclodiol (developmental code name ZK-115194; also known as 14α,17α-ethano-17β-estradiol) is a synthetic estrogen which was studied in the 1990s and was never marketed. It is a derivative of estradiol with a bridge between the C14α and C17α positions. Cyclodiol has 100% of the relative binding affinity of estradiol for the human ERα and similar transactivational capacity as estradiol at the receptor. It has comparable potency to estradiol when administered by subcutaneous injection. The drug shows genotoxicity similarly to estradiol. Cyclodiol showed an absolute bioavailability of 33 ± 19% and an elimination half-life of 28.7 hours in pharmacokinetic studies in women.

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