Minted: - / 5000

3997 Urapidil
37b5ecc315458e468e016783134ed76152f64bc9cf7bf4b0484f801f6b7fa82b

Properties

Background

Blue
Bottle

Purple
Cap

Light blue
Syringe

Blue
Bubbles
No
Drops
Yes
Label
Leaf

Chemistry

Formula
C20H29N5O3
Carbon
20
Polarity
Neutral

Urapidil is a sympatholytic antihypertensive drug. It acts as an α₁-adrenoceptor antagonist and as an 5-HT_1A receptor agonist. Although an initial report suggested that urapidil was also an α₂-adrenoceptor agonist, this was not substantiated in later studies that demonstrated it was devoid of agonist actions in the dog saphenous vein and the guinea-pig ileum. Unlike some other α₁-adrenoceptor antagonists, urapidil does not elicit reflex tachycardia, and this may be related to its weak β₁-adrenoceptor antagonist activity, as well as its effect on cardiac vagal drive. Urapidil is currently not approved by the U.S. Food and Drug Administration, but it is available in Europe.

From Wikipedia, the free encyclopedia. License: CC BY-SA.