Minted: - / 5000

4071 Frakefamide
2ab00e79aad6bd87829bfd35b5462b4c376db8c50b773171147da009a52d8d26

Properties

Background

Yellow
Bottle

Blue
Cap

Green
Syringe

Orange
Bubbles
No
Drops
No
Label
-

Chemistry

Formula
C30H34FN5O5
Carbon
30
Polarity
Neutral

Frakefamide (INN) is a synthetic, fluorinated linear tetrapeptide with the amino acid sequence Tyr-D-Ala-(p-F)Phe-Phe-NH₂ which acts as a peripherally-specific, selective μ-opioid receptor agonist. Despite its inability to penetrate the blood-brain-barrier and enter the central nervous system, frakefamide has potent analgesic effects and, unlike centrally-acting opioids like morphine, does not produce respiratory depression, indicating that its antinociceptive effects are mediated by peripheral μ-opioid receptors. It was under development for the treatment of pain by AstraZeneca and Shire but was shelved after phase II clinical trials.

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