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4164 Xanomeline
448158624a7516bb64c22247cb916f09bc48a776f40788978b32ac306eea2d61

Properties

Background

Green
Bottle

Red
Cap

Light blue
Syringe

Yellow
Bubbles
No
Drops
No
Label
Bacterium

Chemistry

Formula
C14H23N3OS
Carbon
14
Polarity
Neutral

Xanomeline (LY-246,708; Lumeron, Memcor) is a muscarinic acetylcholine receptor agonist with reasonable selectivity for the M₁ and M₄ subtypes, though it is also known to act as a M₅ receptor antagonist. It has been studied for the treatment of both Alzheimer's disease and schizophrenia, particularly the cognitive and negative symptoms, although gastrointestinal side effects led to a high drop-out rate in clinical trials. Despite this, xanomeline has been shown to have reasonable efficacy for the treatment of schizophrenia symptoms, and one recent human study found robust improvements in verbal learning and short-term memory associated with xanomeline treatment.

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