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4190 Siramesine
e8b75d8018045e49b705ccd7ecb389e724cc2bb3879571b078a071bc97c4c823

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Properties

Chemistry

Siramesine (or Lu 28-179) is a sigma receptor agonist, selective for the σ2 subtype. In animal studies, siramesine has been shown to produce anxiolytic and antidepressanteffects. It was developed by the pharmaceutical company H Lundbeck for the treatment of anxiety, although development was discontinued after clinical trials showed a lack of efficacy in humans.

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