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4199 Sonepiprazole
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Properties

Background

Gray
Bottle

Green
Cap

Yellow
Syringe

Red
Bubbles
Yes
Drops
No
Label
Bacterium

Chemistry

Formula
C21H27N3O3S
Carbon
21
Polarity
Neutral

Sonepiprazole (U-101,387, PNU-101,387-G) is a drug of the phenylpiperazine class which acts as a highly selective D₄ receptor antagonist. In animals, unlike D₂ receptor antagonists like haloperidol, sonepiprazole does not block the behavioral effects of amphetamine or apomorphine, does not alter spontaneous locomotor activity on its own, and lacks extrapyramidal and neuroendocrine effects. However, it does reverse the prepulse inhibition deficits induced by apomorphine, and has also been shown to enhance cortical activity and inhibit stress-induced cognitive impairment. As a result, it was investigated as an antipsychotic for the treatment of schizophrenia in a placebo-controlled clinical trial, but in contrast to its comparator olanzapine no benefits were found and it was not researched further for this indication.

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