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4294 Alstonine
c2a839dc8155c9e64f42d4347730f0ef245bf1230c05d6d0087838037f612e2b

Properties

Background

Blue
Bottle

Green
Cap

Green
Syringe

Pink
Bubbles
No
Drops
Yes
Label
Cross

Chemistry

Formula
C21H20N2O3
Carbon
21
Polarity
Neutral

Alstonine is an indoloquinolizidine alkaloid and putative antipsychotic constituent of various plant species including Alstonia boonei, Catharanthus roseus, Picralima nitida, Rauwolfia caffra and Rauwolfia vomitoria. In preclinical studies alstonine attenuates MK-801-induced hyperlocomotion, working memory deficit and social withdrawal. It also possesses anxiolytic-like effects in preclinical studies, attenuates amphetamine-induced lethality and stereotypy as well as apomorphine-induced stereotypy, and attenuates haloperidol-induced catalepsy. These effects appear to be mediated by stimulation of the 5-HT_2C receptor. In addition, alstonine, similarly to clozapine, indirectly inhibits the reuptake of glutamate in hippocampal slices. Unlike clozapine however, the effect of which is abolished by the D₂ receptor agonist apomorphine, alstonine requires 5-HT_2A and 5-HT_2C receptors to produce this effect, as it is abolished by antagonists of these receptors. Also unlike clozapine, alstonine lacks pro-convulsant activity in mice.

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