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442 Tolcapone
34f888e2f14b1d76285d669fd221c9fe0c25437e9906ae9c1fc60d66888659b0

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Tolcapone, sold under the brand name Tasmar, is a medication used to treat Parkinson's disease (PD). It is a selective, potent and reversible nitrocatechol-type inhibitor of the enzyme catechol-O-methyltransferase (COMT). It has demonstrated significant liver toxicity, which has led to suspension of marketing authorisations in a number of countries.

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