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444 Deoxygedunin
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Properties

Background

Green
Bottle

Gray
Cap

Green
Syringe

Light green
Bubbles
No
Drops
No
Label
Pill

Chemistry

Formula
C28H34O6
Carbon
28
Polarity
Neutral

Deoxygedunin, or 14,15-deoxygedunin, is a naturally occurring tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica), a plant that has been used in India since ancient times as a remedy for various ailments. Deoxygedunin has been found to act as a potent, selective, small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF). It produces TrkB-dependent neurotrophic and neuroprotective effects in mice and enhances learning processes. In addition, deoxygedunin evokes rapid TrkB-dependent antidepressant-like effects in the forced swim test, an animal model of depression, similarly to 7,8-dihydroxyflavone (7,8-DHF) and ketamine, and notably with a greater potency than 7,8-DHF. The compound was discovered by the same group that identified 7,8-DHF and N-acetylserotonin as TrkB agonists.

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