Minted: - / 5000

4470 Dehydronorketamine
45970ea35a7ee1a669fcabb13af1254c9b2496865dae88fd694a680d44fdd3ec

Properties

Background

Blue
Bottle

Blue
Cap

Light green
Syringe

Red
Bubbles
Yes
Drops
No
Label
Heart

Chemistry

Formula
C12H12ClNO
Carbon
12
Polarity
Neutral

Dehydronorketamine (DHNK), or 5,6-dehydronorketamine, is a minor metabolite of ketamine which is formed by dehydrogenation of its metabolite norketamine. Though originally considered to be inactive, DHNK has been found to act as a potent and selective negative allosteric modulator of the α₇-nicotinic acetylcholine receptor (IC₅₀ = 55 nM). For this reason, similarly to hydroxynorketamine (HNK), it has been hypothesized that DHNK may have the capacity to produce rapid antidepressant effects. However, unlike ketamine, norketamine, and HNK, DHNK has been found to be inactive in the forced swim test (FST) in mice at doses up to 50 mg/kg. DHNK is inactive at the α₃β₄-nicotinic acetylcholine receptor (IC₅₀ > 100 μM) and is only very weakly active at the NMDA receptor (K_i = 38.95 μM for (S)-(+)-DHNK). It can be detected 7–10 days after a modest dose of ketamine, and because of this, is useful in drug detection assays.

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