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4518 Norbinaltorphimine
543d60b36ede3c8317dd9b165b33af0b6467de1dda34652c3d28c0beabca5b42

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Properties

Chemistry

Norbinaltorphimine (nor-BNI or nBNI) is an opioid antagonist used in scientific research. It is one of the few opioid antagonists available that is highly selective for the κ-opioid receptor, and blocks this receptor without affecting the μ- or δ-opioid receptors, although it has less selectivity in vivo than when used in isolated tissues. nor-BNI blocks the effects of κ-opioid agonists in animal models, and produces antidepressant and antipanic-like effects.

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