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4598 Methoctramine
629606993b0cc25c9d9676d7f52d7b024405d267335481740b013fcb09fe76c4

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Properties

Chemistry

Methoctramine is a polymethylene tetraamine that acts as a muscarinic antagonist. It preferently binds to the pre-synaptic receptor M2, a muscarinic acetylcholine ganglionic protein complex present basically in heart cells. In normal conditions -absence of methoctramine-, the activation of M2 receptors diminishes the speed of conduction of the sinoatrial and atrioventricular nodes thus reducing the heart rate. Thanks to its apparently high cardioselectivity, it has been studied as a potential parasymphatolitic drug, particularly against bradycardia. However, currently it’s only addressed for research purposes, since the administration to humans is still unavailable.

From Wikipedia, the free encyclopedia. License: CC BY-SA.
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