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4612 Spiroxasone
9a96ec70425c504f19a806598262ce4c0503ebfe30119f1943a22bb35fb4b2bc

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Properties

Chemistry

Spiroxasone (, ) is a synthetic, steroidal antimineralocorticoid of the spirolactone group which was developed as a diuretic and antihypertensive agent but was never marketed. It was synthesized and assayed in 1963. The drug is 7α-acetylthiospirolactone with the ketone group removed from the C17α spirolactone ring. Similarly to other spirolactones like spironolactone, spiroxasone also possesses antiandrogen activity.

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