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4647 Alestramustine
4622c5f74652aee2abf05f888ce509d6d667c46ce58ceb7a95a8fb291b84d581

Properties

Background

Red
Bottle

Gray
Cap

Blue
Syringe

Light blue
Bubbles
No
Drops
No
Label
-

Chemistry

Formula
C26H36Cl2N2O4
Carbon
26
Polarity
Neutral

Alestramustine , also known as estradiol 3-(bis(2-chloroethyl)carbamate) 17β-(L-alaninate), is a cytostatic antineoplastic agent which was never marketed. It is the L-alanine ester of estramustine, which is a combination of the nitrogen mustard normustine coupled via a carbamate to the estrogen estradiol. Alestramustine acts as a prodrug to estramustine, and also forms estradiol as a byproduct. The drug, via its active metabolites, binds to microtubule-associated proteins and β-tubulin and interferes with microtubule function, thereby inhibiting cell division. Due to its estrogen moiety, alestramustine is selectively concentrated in estrogen receptor-positive cells such as prostate and breast.

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