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4687 Apimostinel
6592474e61376c9682b708a1874cdcd3ca90c9d38a5c2a6029659a99e3aa6681

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Properties

Chemistry

Apimostinel (former developmental code name NRX-1074) is an antidepressant, acting as a selective partial agonist of an allosteric site of the glycine site of the NMDA receptor complex, which is under investigation by Naurex and Allergan for the treatment of major depressive disorder (MDD). As of 2015, an intravenous formulation of apimostinel is in a phase II clinical trial for MDD, and an oral formulation is concurrently in phase I trials for MDD.

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