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4877 Pravadoline
c5f2ec5bf8c852020dce970ad8c7148c9581198d9a5a5e8dbf9ac4286f863b61

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Properties

Chemistry

Pravadoline (WIN 48,098) is an antinflammatory and analgesic drug with an IC50 of 4.9 μM and a Ki of 2511 nM at CB1, related in structure to nonsteroidal anti-inflammatory drugs (NSAIDs) such as indometacin. It was developed in the 1980s as a new antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX).

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