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4894 Tabimorelin
6ab1311f48861e9e834f37e42688f880668a344e6bb98119be2114d6d7f7b9fc

Properties

Background

Brown
Bottle

Yellow
Cap

Light blue
Syringe

Yellow
Bubbles
No
Drops
Yes
Label
Cross

Chemistry

Formula
C32H40N4O3
Carbon
32
Polarity
Neutral

Tabimorelin (INN) (developmental code name NN-703) is a drug which acts as a potent, orally-active agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and growth hormone secretagogue, mimicking the effects of the endogenous peptide agonist ghrelin as a stimulator of growth hormone (GH) release. It was one of the first GH secretagogues developed and is largely a modified polypeptide, but it is nevertheless orally-active in vivo. Tabimorelin produced sustained increases in levels of GH and insulin-like growth factor 1 (IGF-1), along with smaller transient increases in levels of other hormones such as adrenocorticotropic hormone (ACTH), cortisol, and prolactin. However actual clinical effects in adults with growth hormone deficiency were limited, with only the most severely GH-deficient patients showing significant benefit, and tabimorelin was also found to act as a CYP3A4 inhibitor which could cause it to have undesirable interactions with other drugs.

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